{ "cells": [ { "cell_type": "markdown", "metadata": { "vscode": { "languageId": "html" } }, "source": [ "## Metabolic interactions in the tumor microenvironment\n", "\n", "
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"**Explore metabolic interactions within the tumour microenvironment** by analyzing the exchange of metabolites between spatially adjacent spots.\n",
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"\n", "\n", "- **Interaction Scores** \n", " Quantify the **strength** of metabolite exchange between spatially adjacent spots.\n", "\n", "- **Interaction Types**\n", " - **Competition** — Spatially adjacent spots (cells) compete for the metabolites available in the microenvironment. \n", " - **Release** — Spatially adjacent cells engage in metabolite exchange that benefits both, typically where a metabolite secreted by one cell is taken up and utilized by another.\n", " - **Cooperation** — Cells secrete metabolites into the microenvironment without evidence of uptake by neighboring cells, contributing to the shared metabolite pool. \n", " - **Amensalism** — One cell either secrets or consumes the metabolite, while spatially adjacent cell do not utilize it.\n", " - **Neutralism** — Spatially adjacent cells coexist without detectable metabolic interaction, showing no significant exchange or competition for metabolites.\n", " | \n", "